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產(chǎn)品中心抗體Polyclonal AntibodyK106719PAnti-CDK4 Polyclonal Antibody
產(chǎn)品型號：K106719P
更新時間：2022-08-15
廠商性質(zhì)：生產(chǎn)廠家
訪 問 量 ：1010
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Anti-CDK4 Polyclonal Antibody
| 英文名稱 | Anti-CDK4 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | CDK4;Cell division protein kinase 4;CMM3;cyclin dependent kinase 4;PSK J3 |
| 應用 | IHC |
| 稀釋比例 | IHC 1:50-200. |
| 交叉反應 | Human |
| 蛋白分子量 | 34kDa |
| Gene ID | 1019 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | Recombinant protein of human CDK4 |
| 性狀 | 液體 |
| Public Immunogen Range | Recombinant protein of human CDK4 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | P11802 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. |
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